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| Data Details |
| Disease Name |
liver cirrhosis |
| Tissue |
liver |
| Database |
ArrayExpress |
| Data ID |
E-MTAB-7298 |
| Data Type |
expression |
| Platform |
N/A |
| Species |
rattus norvegicus |
| Sample Number |
6 |
| PubMed ID |
|
| Title |
Transcription profiling of rat hepatic stellate cells after siRNA kockdown of SOX9 to study its role in liver fibrosis |
| Data Description |
"Extracellular matrix (ECM) deposition and resultant scar play a major role in the pathogenesis and progression of liver fibrosis. Identifying core regulators of ECM deposition may lead to urgently needed diagnostic and therapetic strategies for the disease. The transcription factor Sex determining region Y box 9 (SOX9) is actively involved in scar formation and its prevalence in patients with liver fibrosis predicts progression. In this study, transcriptomic approaches of Sox9-abrogated myofibroblasts identified >30% of genes regulated by SOX9 relate to the ECM." |
| Keyword |
liver fibrosis sirna |
| Download |
Download Link
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